|
KMID : 0356619860010020125
|
|
Journal of Korean Society of Endocrinology
1986 Volume.1 No. 2 p.125 ~ p.125
|
|
|
Kinetic Parameters of Turnover of Catecholamines and 5-HT in the Rat Hypothalamus during Stress-Roles of Monoamines in the Regulation of HPA Axis(Ⅴ)
|
|
Suh, Yoo Hun
Kim, Yong Sik/Woo, Song Inn/Park, Chan Woong
|
|
|
Abstract
|
|
|
It is generally recognized that central nervous system plays an essential role in the regulation of synthesis and release of ACTH. It is now firmly estabilished that the hypothalamus is the focal point at which neural stimuli convergo to influence the secretion of ACTH, and the median eminence is regarded as the final common path throygh which information is transmitted to the anterior pituitary.
In recent years, efforts have been directed toward and progress has been made in identifying some of the neurotransmitters that control the release of corticotropin-releasing factor (CRF). Among them, monoaminergic neural systems in the hypothalmic control of pituitary function have been widely studied. Possible roles of brain catecholamines and serotonin in the regulation of ACTH secretion have been considered by numerous investigator. The catecholamines and serotonin are not per se the hypothalamic corticotropin releasing factors (Saffran and Schally, 1955; Guillemin and Rosenberg, 1955; Martini et al., 1960; Fischer and Moriarty, 1977).
Some have propsed the hypothesi thar serotonin is a stimulatory neurotransmitter involved in the stress responsiveness of HPA (Fuller et al., 1976; Jones et al., 1976, 1979; Knych and Eisenberg, 1979, 1980; Krieger and Krieger, 1970, 1975; Meyer et al.: 1978; Popova et al., 1975; Steiner and Grahame Smoth, 1980).
In the other hand, the results of several investigations have led to oppostie conclusion (Berger et al., 1974; Kovacs et al., 1976; Pavel et al., 1977; Telegdy and Vermes, 1973; Vermes et al., 1972, 1974; Vernikos-Danellis, 1973, 1980; Westerman et al., 1962).
Several groupsof investigators have reported increased adrenal corticosteroid secretion following the injection of catecholamines directly into the brain (Endrpczi et al., 1963; Krieger and Krieger, 1965).
On the other hand numerous studied have failed to support an excitatory role of brain cateholamines in the regulation of ACTH secreion but have led to the opposite (Smelik, 1967; Carr and Moore, 1968; an Loon et al., 1971a, b, c; Scapagnini et al., 1970, 1971; Ganong et al., 1976; Ganong, 1977; Steiner and Grahame-Smith, 1980).
This study was undertaken to try to clarify the role of catecholamines in the hypothalamopituitary-adreno-cortical response to stress. The aims of the present study were to check the kinetix parameters of turnover of catcholamines and serotonin as well as steady state conncentrations in the hypothalamus before and after ether stress.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|